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Advanced Heart Failure

What is advanced heart failure?

Advanced heart failure is when you have heart failure that’s getting worse, even though you’re taking standard medications and making lifestyle changes. It’s not a different disease; it’s a more advanced form of heart failure.

The American Heart Association and the American College of Cardiology use these four stages to describe heart failure:

  • Stage A: At risk for heart failure
  • Stage B: Pre-heart failure
  • Stage C: Symptomatic heart failure
  • Stage D: Advanced heart failure

The New York Heart Association (NYHA) separates stage C and stage D into four levels, or classes:

  • Class 1: Your heart failure doesn’t limit your physical activity. With ordinary physical activity, you don’t notice much fatigue, palpitations (rapid heartbeat) or shortness of breath.
  • Class 2: You start to notice limits to what you can do. You may be comfortable at rest, but ordinary physical activity may cause fatigue, palpitations, shortness of breath or chest pain.
  • Class 3: You’re comfortable at rest but even a small amount of activity may cause fatigue, palpitations, shortness of breath or chest pain.
  • Class 4: You have symptoms at rest and activity makes them worse. 

What symptoms may signal that heart failure is getting worse?

Even when you’re on the right heart failure medications, you may still notice signs of worsening heart failure such as:

  • Feeling tired or weak, even with small amounts of activity
  • Shortness of breath when you’re resting or lying down
  • Being hospitalized due to too much fluid in your lungs
  • Loss of appetite
  • Unexpected weight loss Swelling in your legs, ankles or abdomen

Learn more about heart failure symptoms.

What are common risk factors for advanced heart failure?

Common risk factors include:

  • Unmanaged heart failure symptoms
  • Refractory coronary artery disease (long-term chest pain that lasts even after you’ve tried medication and surgery)
  • Having one or more heart attacks in the past
  • Uncontrolled or poorly controlled high blood pressure
  • Uncontrolled or poorly controlled diabetes
  • Metabolic syndrome, which is when you have three or more of these conditions: too much fat at the waist, high cholesterol, high triglycerides, high blood pressure or high blood sugar
  • Obesity
  • Untreated heart valve disease
  • Cardiomyopathy, a disease where it’s hard for your heart to pump blood
  • Not taking medications as you are supposed to or not following your care plans
  • Refractory arrhythmias, which are heart rhythm problems that don’t go away with treatment, like persistent atrial fibrillation (AFib)

How is advanced heart failure diagnosed?

To diagnose advanced or treatment-resistant heart failure, your health care provider will ask you to track your symptoms and will check your health.

They may order: 

  • Echocardiogram: This test can measure your ejection fraction, which shows how well your heart is pumping blood.
  • Cardiac MRI: This imaging test can show how much damage there is to your heart.
  • Blood tests: High levels of B-type natriuretic peptide (BNP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) can be a sign of advanced heart failure.
  • Left heart catheterization: This test checks the arteries that bring blood to your heart for blockages.
  • Right heart catheterization: This test can measure blood pressure in your heart and lungs.
  • Cardiopulmonary exercise stress testing: This test can help determine how severe your heart failure is.

If you may be a candidate for mechanical circulatory support (MCS) or a heart transplant, your provider will have you see other specialists to find out if you qualify.

What are treatment options for advanced heart failure?

Heart failure treatment options you can try beyond standard medication may include:

  • Percutaneous valve interventions: Valve repairs or replacements that can be done without surgery
  • High risk coronary intervention: Procedures that help open blocked or clogged arteries so more blood can get to the heart
  • Specialized ablative therapies: Treatments that block abnormal electrical signals in the heart, used for arrhythmias
  • IV inotropes: These medications help make your heart beat stronger, so blood can get to your body
  • Advanced medications: Your provider may recommend other drugs to help with heart failure

Implantable device options include:

  • Implantable cardioverter-defibrillators (ICDs): Devices that can stop irregular heartbeats 
  • Cardiac-resynchronization therapy defibrillator (CRT-D): Devices that correct unusual heart rhythms and use signals to tell your heart when to beat
  • Cardiac contractility modulation (CCM): Devices that may help with some heart failure symptoms and also help your heart work better
  • Barostim: Devices that are similar to pacemakers, but they tell the brain to lower levels of stress hormones, so your heart doesn’t work as hard

You may need mechanical circulatory support (MCS), which could include:

  • Left ventricular assist device (LVAD): A battery-operated pump that helps your heart pump blood to your body
  • Total artificial heart (TAH): A pump that replaces your heart to send blood through your body and make sure your organs get enough blood until you can get a heart transplant
  • Temporary heart pumps: Other assist devices that help circulate your blood until you can get other treatment, like transplant

If you have advanced heart failure, you may qualify for a heart transplant. This depends on the condition of your heart, your overall wellness, your age, your blood type and more.

You may also choose palliative care, which can help reduce your pain and symptoms and give you a sense of control over the care you get.

When should you seek advanced heart care?

Ask your cardiologist for a referral to a Banner Health advanced heart care specialist if:

  • You have Class 3 or 4 heart failure symptoms
  • You’ve been hospitalized for heart failure once or more in the last year
  • Your ejection fraction is low even though you’re following your treatment plan
  • You can’t tolerate medications, so your provider is reducing them
  • Your quality of life is poor

What support can you get from Banner Health’s care team?

Care for advanced heart failure at Banner Health includes:

  • Specialized heart failure clinics
  • Experts in heart transplant and MCS 
  • Nutrition, medication and emotional support services to help with all the ways advanced heart failure impacts your life
  • Case management and remote monitoring so your care team is up to date on any changes in your symptoms or condition
  • Patient navigators who can help you with complex care plans
  • Cardiac rehabilitation 

FAQs and related resources

What is the difference between heart failure and advanced heart failure?

Heart failure is when your heart is weak or stiff and can’t pump blood properly. Advanced heart failure is when your symptoms keep getting worse, even though you’re following your treatment plan for heart failure.

How do I know if I need a heart transplant?

You may need a heart transplant if the treatments you’ve tried for advanced heart failure aren’t working, so your quality of life and life expectancy are reduced.

How do I know if I qualify for a heart transplant?

To find out if you qualify, a team that may include a cardiologist, surgeon, social worker, nutritionist, behavioral health specialist and other experts will recommend tests and screening exams. 

What are my options if I’m not a heart transplant candidate?

If you don’t qualify for a heart transplant, you may be able to use an LVAD or have other surgeries that may help your heart work better.

How do I know if I qualify for an LVAD?

Your health care team can help you find out if you qualify for an LVAD. Generally, you need to have class 3 or 4 heart failure. Having some other health conditions, like liver, kidney, lung or blood clotting problems, may mean you don’t qualify for an LVAD. 

Learn more:

Why choose Banner Health for advanced heart failure care? 

When you choose Banner Health for advanced heart failure, you benefit from our:

  • Heart transplant and MCS programs, where we treat a high number of patients and have a high success rate
  • Teams of specialists in different departments who work together to provide your care 
  • Locations across the Southwest where you can connect with care
  • Long-term management that focuses on your quality of life

Schedule an evaluation or referral

If you or someone you love has heart failure that’s getting worse, we’re here to help.

Find a Banner heart specialist near you.