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Flu Antiviral Medications

Just like the flu shot can help prevent the flu (influenza), antiviral medications can reduce how long you're sick. This is especially helpful for people in high-risk groups.

At Banner Health, your health and well-being are our top priorities. Here's what you need to know about how antiviral medications work, who should take them and how they can help.

What are flu antiviral medications?

Flu antivirals are prescription drugs available as pills, liquids, inhalers or IV medications. They work by stopping the flu virus from multiplying, helping you recover faster and reducing the risk of complications.

What flu antivirals are available?

here are four Food and Drug Administration (FDA)-approved antiviral drugs for flu treatment. These medications target influenza A and B viruses, which are most common during flu season. The most prescribed are neuraminidase inhibitors, which block a protein the flu virus needs to spread: 

  • Oseltamivir phosphate (Tamiflu): Pill or liquid form. Safe for adults and children as young as 2 weeks. Preferred for pregnant women and young children.
  • Zanamivir (Relenza): Inhaled powder. For ages 7 and up. Not recommended for people with asthma or COPD. 
  • Peramivir (Rapivab): IV form. For adults and children older than 6 months. 

Another antiviral, baloxavir marboxil (Xofluza), works differetly:

  • Baloxavir marboxil (Xofluza): Single-dose pill. Approved for children ages 5–11 without chronic conditions and everyone 12 and older. Not recommended during pregnancy or while breastfeeding.

What are the benefits of taking flu antivirals?

Early antiviral treatment—within 48 hours of symptom onset—can:

  • Shorten flu symptoms by about one day
  • Lower the risk of serious complications like pneumonia, ear infections and hospitalization
  • Reduce the spread of the virus to others 

Who should take flu antiviral medication?

Flu antivirals work best when taken within two days of getting sick and are especially important for: 

People at high risk for flu complications, including: 

  • Children under 5 
  • Adults over 65 
  • Pregnant people 
  • People with chronic medical conditions (like asthma or diabetes) 
  • People with weakened immune systems

People with severe symptoms, such as:

  • Trouble breathing
  • Chest or belly pain
  • Dizziness or confusion

Talk with your health care provider if you think you need antiviral treatment. 

Can antivirals prevent infection?

Can flu antivirals prevent infection? 

Some flu antivirals can also be used to prevent flu in certain situations, though this is not a substitute for getting vaccinated. 

Your provider may recommend preventive antivirals if you: 

  • Are high risk and can’t receive the flu vaccine 
  • Are high risk and were exposed to the flu 
  • Care for or live with someone who is high risk and were exposed 
  • Work in a hospital or long-term care facility with a flu outbreak 

What are the side effects of flu antivirals?

According to the CDC, side effects vary by medication: 

  • Tamiflu (oseltamivir): Nausea, vomiting, headache, and potential kidney concerns 
  • Relenza (zanamivir): Runny nose, dizziness, airway narrowing (not for asthma/COPD) 
  • Rapivab (peramivir): Diarrhea, blood sugar or white blood cell changes; kidney monitoring recommended 
  • Xofluza (baloxavir): Diarrhea, cough, nausea, sinusitis, headache, possible allergic reactions 

Always discuss your medical history and medications with your provider to choose the safest option

Can I take antibiotics to treat the flu?

No. Antibiotics only treat bacterial infections. The flu is caused by a virus, so it won’t respond to antibiotics. 

Flu antivirals are different from those used to treat other viruses, like COVID-19. They specifically target the flu virus. 

What are emergency symptoms to watch for?

Call your health care provider or seek immediate medical care if you or a loved one has/is:

  • Trouble breathing
  • Chest or belly pain
  • Dizziness or confusion
  • Repeated vomiting or diarrhea
  • Coughing up blood
  • Difficulty staying awake or unresponsive behavior 

Learn more about seeking medical care for the flu.

It’s not too late to get your flu shot

Flu antivirals treat influenza, but the best way to prevent it is still getting vaccinated. Multiple strains of flu circulate each season, and the flu shot offers protection against the most common ones. 

Even if you've already had the flu this season, a flu shot can help protect you from getting sick again with a different strain. 

Learn more about flu vaccination and common myths and facts about flu shots.

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